SCHEDULED MAINTENANCE
Molybdenum-mediated reductive deuteration of nitroarenes with D2O: synthesis of ortho- and para-deuterated anilines†
Ming
Lang 
*a
and
Jin-Bao
Peng
*a
*a
and
Jin-Bao
Peng
*a
Abstract
A unique and practical molybdenum-mediated reductive deuteration of nitroarenes for the selective synthesis of ortho- and para-deuterated anilines has been developed. Using Mo(CO)6 as the reductant and the catalyst and D2O as a cheap and operationally convenient D-source, a range of deuterated anilines were prepared from the corresponding nitroarenes with high yields and reliable deuteration levels. High regioselectivity was observed where deuterium incorporation took place selectively at the ortho- and para-positions. Notably, functional groups such as ether, thioether, acetyl and halides were compatible in this reaction without affecting the regioselectivity.
Please wait while we load your content...
